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Not only is there reduced production of melatonin and adrenalin in vitamin B12 deficiency, because of the requirement for methylation, there is also reduced production of CoQ10 and creatine , which are arguably the main contributing factors to the chronic fatigue seen in CFS, as these result in poor energy conversion, and gradual loss of stored muscle creatine

Stochkendahl MJ, Kjaer P, Hartvigsen J, Kongsted A, Aaboe J, Andersen M, et al

Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFB p65 signal pathway